As well as requiring us to honour our parents, the Fifth Commandment also draws our attention to others who are to be accorded our respect, including in the government and the church, 1 Timothy 2:1-7. In honouring our parents, we may sometimes have to disobey them, Matthew 12:46-50.
This commandment is mentioned with a corollary in Ephesians: that parents must not exasperate their children. Parents should aim to make their children discerning so that they can live themselves and start the cycle again with their own children.
Turning against parents is characteristic of those who turn against God, Romans 1:30, Matthew 10:35-39, 15:1-9. Jesus set the highest example of honouring His parents, John 19:25-27.